Education

• PhD student at Cambridge University (current)
• Diploma in Molecular Biomedicine , University of Bonn

Publications and Conference Presentations

• Mapping small molecule binding to protein domains Krüger FA, Overington JP. (oral presentation at InCoB2012, Long Beach, California) [online]

• Data integration illustrates evolutionary mechanisms of ligand selectivity between related protein targets Krüger FA, Overington JP. (oral and poster presentation at ISMB2012, Long Beach, California) [F1000]

• Global analysis of small molecule binding affinities to related protein targets. Krüger FA, Overington JP. PLoS Comput Biol 2012 8(1): e1002333 [online]

• A data integration approach reveals species-specific pharmacology between human and rat orthologs Krüger FA, Overington JP. (poster presentation at ISCB Rocky2011, Snowmass, Colorado) [F1000]

• Collation and data-mining of literature bioactivity data for drug discovery. Bellis LJ et al. Biochem Soc Trans. 2011 Oct;39(5):1365-70.[online]

• Global mapping of ligand and target binding spaces. Krüger FA (oral presentation at ICCS 2011, Nordwijkerhout) [online]

• Global mapping of small molecule binding affinities to homologous proteins. Krüger FA and Overington JP. (poster presentation at Young Modeler's Forum 2010, London) [online]

• Fragment formal concept analysis accurately classifies compounds with closely related biological activities. Krüger F, Lounkine E, Bajorath J. ChemMedChem. 2009 Jul;4(7):1174-81. [online]

Projects

Diploma thesis in Jürgen Bajorath's group, University of Bonn

Fragment formal concept analysis to predict within-gene family selectivity of small molecules

[download my thesis]

Internship in Yechiel Shai's group at the Weizmann Institute, Rehovot

Synthesis of lipopeptides with antibacterial activity

Internship in Jorg Rademann's group at FMP, Berlin

Synthesis of fluorescently labelled peptides to probe protease activity

Related Experience

• Associate Faculty member at F1000 since April 2011
• Co-organizer of the mini-symposium Going for Gold: The Science behind Sporting Success
• Organizer of the mini-symposium Biodiversity and Endangered Species - Rethinking the Balance of Nature
• Member of the organizing team for eSCAMPS2010