Felix A Kruger
Bioinformatician at BenevolentAI, London
google scholar|thesis|cv
Welcome to my website!
I am a Bioinformatician at BenevolentAI in London. My interests are in genetics, chemical biology and molecular evolution.
Previous to my post at BenevolentAI, I was a researcher at the Farr Institute London, where I worked with Aroon Hingorani from UCL and Juan-Pablo Casas from London School of Hygiene and Tropical Medicine, developing approaches to leverage genetic information from large patient cohorts for drug repurposing applications.
I obtained a PhD in Computational Biology from the University of Cambridge, working in John Overington’s group at the European Bioinformatics Institute.
In my thesis research, I integrated bioactivity data from the ChEMBL database with homology information from EnsemblCompara as well as the Pfam collection of protein families. This integration work allowed me to systematically analyse measured small molecule bioactivities in the context of protein evolution - for example by comparing susceptibility to small molecule perturbation in two relevant species, human and rat. You can download my thesis here.
Publications and Conference Presentations
- Mapping small molecule binding to protein domains Krüger FA, Overington JP. (oral presentation at InCoB2012, Long Beach, California) [online]
- Data integration illustrates evolutionary mechanisms of ligand selectivity between related protein targets Krüger FA, Overington JP. (oral and poster presentation at ISMB2012, Long Beach, California) [F1000]
- Global analysis of small molecule binding affinities to related protein targets. Krüger FA, Overington JP. PLoS Comput Biol 2012 8(1): e1002333 [online]
- A data integration approach reveals species-specific pharmacology between human and rat orthologs Krüger FA, Overington JP. (poster presentation at ISCB Rocky2011, Snowmass, Colorado) [F1000]
- Collation and data-mining of literature bioactivity data for drug discovery. Bellis LJ et al. Biochem Soc Trans. 2011 Oct;39(5):1365-70.[online]
- Global mapping of ligand and target binding spaces. Krüger FA (oral presentation at ICCS 2011, Nordwijkerhout) [online]
- Global mapping of small molecule binding affinities to homologous proteins. Krüger FA and Overington JP. (poster presentation at Young Modeler’s Forum 2010, London) [online]
- Fragment formal concept analysis accurately classifies compounds with closely related biological activities. Krüger F, Lounkine E, Bajorath J. ChemMedChem. 2009 Jul;4(7):1174-81. [online]
CV
2010 - 2014: PhD in Computational Biology, Cambridge University
2004 - 2009: Diploma in Molecular Biomedicine, University of Bonn
Download full CV here.